Search for publications

Publications involving our NucleoCounter® instruments.

Search here

Instruments
Assays
Cell Types
Research Area

2024

A Novel Method for Real-Time Quantification of Radioligand Binding to Living Tumor Cells In Vitro

  • Bäck T, Albertsson P, Aneheim E, et al. ,

  • Cancer Biother Radiopharm ,

  • 2024,

  • Instrument : NucleoCounter® NC-200™
  • Cell Type: Cancer Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Oncology​

Background: Real-time quantification of radioligand binding to cells under in vivo-like conditions improves evaluation of clinical potential. Materials and Methods: SKOV-3 tumor cells were grown in a monolayer on a thin glass plate placed in a sealable shallow chamber with...

View Publication

Cultivated Meat from Aligned Muscle Layers and Adipose Layers Formed from Glutenin Films

  • Yao Y, Yuen JSK Jr, Sylvia R, et al. ,

  • ACS Biomater Sci Eng ,

  • 2024,

  • Instrument : NucleoCounter® NC-200™
  • Cell Type: Mammalian Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Cultured Meat​

Cultivated meat production is a promising technology to generate meat while reducing the reliance on traditional animal farming. Biomaterial scaffolds are critical components in cultivated meat production, enabling cell adhesion, proliferation, differentiation, and orientation. In the present work, naturally derived...

View Publication

Extracellular vesicle biogenesis of three-dimensional human pluripotent stem cells in a novel Vertical-Wheel bioreactor

  • Muok L, Sun L, Esmonde C, et al. ,

  • Journal of Extracellular Biology ,

  • 2024,

  • 3(1):e133

  • Instrument : NucleoCounter® NC-200™
  • Cell Type: iPSCs & ESCs
  • Assay: Cell Count & Viability Assay
  • Research area: Stem Cell Research

Extracellular vesicles (EVs) secreted by human‐induced pluripotent stem cells (hiPSCs) have great potential as cell‐free therapies in various diseases, including prevention of blood–brain barrier senescence and stroke. However, there are still challenges in pre‐clinical and clinical use of hiPSC‐EVs due...

View Publication

2023

Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency

  • Lund M, Heaton R, Hargreaves IP, et al. ,

  • Biochim Biophys Acta Mol Cell Biol Lipids ,

  • 2023,

  • 1868(2):159248

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Primary Cells
  • Assay: Cell Vitality Assay
  • Research area: Cell Biology​

Recent trials have reported the ability of triheptanoin to improve clinical outcomes for the severe symptoms associated with long-chain fatty acid oxidation disorders, including very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency. However, the milder myopathic symptoms are still challenging to treat...

View Publication
  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Cell Count & Viability Assay, Cell Cycle Assay
  • Research area: Oncology​

The presence of di-(2-ethylhexyl) phthalate (DEHP) in the aquatic systems, specifically marine sediments has attracted considerable attention worldwide, as it enters the food chain and adversely affects the aquatic environment and subsequently human health. This study reports an efficient carbocatalytic...

View Publication
  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Annexin V Assay, Cell Cycle Assay
  • Research area: Oncology​

Doxorubicin (DOX) is one of the most used chemotherapeutic agents in the treatment of various types of cancer. However, a continual problem that is associated with its application in therapeutic regimens is the development of dose-dependent cardiotoxicity. The progression of...

View Publication

2022

Designing and executing prime editing experiments in mammalian cells

  • Doman JL, Sousa AA, Randolph PB, et al. ,

  • Nat Protoc ,

  • 2022,

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Mammalian Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Gene Therapy

Prime editing (PE) is a precision gene editing technology that enables the programmable installation of substitutions, insertions and deletions in cells and animals without requiring double-strand DNA breaks (DSBs). The mechanism of PE makes it less dependent on cellular replication...

View Publication

Needle to needle robot-assisted manufacture of cell therapy products

  • Ochs J, Hanga MP, Shaw G, et al. ,

  • Bioeng Transl Med ,

  • 2022,

  • e10387

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: MSCs
  • Assay: Cell Count & Viability Assay
  • Research area: Stem Cell Therapy​

Advanced therapeutic medicinal products (ATMPs) have emerged as novel therapies for untreatable diseases, generating the need for large volumes of high-quality, clinically-compliant GMP cells to replace costly, high-risk and limited scale manual expansion processes. We present the design of a...

View Publication

In vitro toxicological assessment of PhSeZnCl in human liver cells

  • di Vito R, Levorato S, Fatigoni C, et al. ,

  • Toxicological Research ,

  • 2022,

  • 01/Oct

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Cell Count & Viability Assay, Cell Cycle Assay, DNA Fragmentation Assay, Mitochondrial Potential Assay
  • Research area: Oncology​

Phenylselenenylzinc chloride (PhSeZnCl) is an air-stable selenolate, easily synthesizable through oxidative insertion of elemental zinc into the Se-halogen bond of the commercially available phenylselenyl chloride. PhSeZnCl was shown to possess a marked GPx-like activity both in NMR and in vitro...

View Publication