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Publications involving our NucleoCounter® instruments.

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2023

Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency

  • Lund M, Heaton R, Hargreaves IP, et al. ,

  • Biochim Biophys Acta Mol Cell Biol Lipids ,

  • 2023,

  • 1868(2):159248

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Primary Cells
  • Assay: Cell Vitality Assay
  • Research area: Cell Biology​

Recent trials have reported the ability of triheptanoin to improve clinical outcomes for the severe symptoms associated with long-chain fatty acid oxidation disorders, including very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency. However, the milder myopathic symptoms are still challenging to treat...

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  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Cell Count & Viability Assay, Cell Cycle Assay
  • Research area: Oncology​

The presence of di-(2-ethylhexyl) phthalate (DEHP) in the aquatic systems, specifically marine sediments has attracted considerable attention worldwide, as it enters the food chain and adversely affects the aquatic environment and subsequently human health. This study reports an efficient carbocatalytic...

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  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Annexin V Assay, Cell Cycle Assay
  • Research area: Oncology​

Doxorubicin (DOX) is one of the most used chemotherapeutic agents in the treatment of various types of cancer. However, a continual problem that is associated with its application in therapeutic regimens is the development of dose-dependent cardiotoxicity. The progression of...

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2022

Designing and executing prime editing experiments in mammalian cells

  • Doman JL, Sousa AA, Randolph PB, et al. ,

  • Nat Protoc ,

  • 2022,

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Mammalian Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Gene Therapy

Prime editing (PE) is a precision gene editing technology that enables the programmable installation of substitutions, insertions and deletions in cells and animals without requiring double-strand DNA breaks (DSBs). The mechanism of PE makes it less dependent on cellular replication...

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Needle to needle robot-assisted manufacture of cell therapy products

  • Ochs J, Hanga MP, Shaw G, et al. ,

  • Bioeng Transl Med ,

  • 2022,

  • e10387

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: MSCs
  • Assay: Cell Count & Viability Assay
  • Research area: Stem Cell Therapy​

Advanced therapeutic medicinal products (ATMPs) have emerged as novel therapies for untreatable diseases, generating the need for large volumes of high-quality, clinically-compliant GMP cells to replace costly, high-risk and limited scale manual expansion processes. We present the design of a...

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In vitro toxicological assessment of PhSeZnCl in human liver cells

  • di Vito R, Levorato S, Fatigoni C, et al. ,

  • Toxicological Research ,

  • 2022,

  • 01/Oct

  • Instrument : NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Cell Count & Viability Assay, Cell Cycle Assay, DNA Fragmentation Assay, Mitochondrial Potential Assay
  • Research area: Oncology​

Phenylselenenylzinc chloride (PhSeZnCl) is an air-stable selenolate, easily synthesizable through oxidative insertion of elemental zinc into the Se-halogen bond of the commercially available phenylselenyl chloride. PhSeZnCl was shown to possess a marked GPx-like activity both in NMR and in vitro...

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