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2022

Genotoxic and inflammatory effects of spruce and brown coal briquettes combustion aerosols on lung cells at the air-liquid interface

  • Ihantola T, Hirvonen MR, Ihalainen M, et al. ,

  • Science of The Total Environment ,

  • 2022,

  • 860;150489

  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Epithelial Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Cell Biology

Solid fuel usage in residential heating and cooking is one of the largest sources of ambient and indoor air particulate matter, which causes adverse effects on the health of millions of peoples worldwide. Emissions from solid fuel combustion, such as...

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Potential Anticancer Agents against Melanoma Cells Based on an As-Synthesized Thiosemicarbazide Derivative

  • Kozyra P, Korga-Plewko A, Karczmarzyk Z, et al. ,

  • Biomolecules ,

  • 2022,

  • 12(2):151

  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Cell Cycle Assay, Cell Vitality Assay
  • Research area: Oncology

In this paper, thiosemicarbazide derivatives were synthesized as potential anticancer agents. X-ray investigations for 1-(2,4-dichlorophenoxy)acetyl-4-(2-fluorophenyl) thiosemicarbazide, 1-(2,4-dichlorophenoxy)acetyl-4-(4-metylothiophenyl)thiosemicarbazide and 1-(2,4-di chlorophenoxy)acetyl-4-(4-iodophenyl)thiosemicarbazide were carried out in order to confirm the synthesis pathways, identify their tautomeric forms, analyze the conformational preferences of molecules,...

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  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Cancer Cells
  • Assay: Annexin V Assay, Cell Count & Viability Assay, Cell Cycle Assay, Cell Vitality Assay, Mitochondrial Potential Assay
  • Research area: Oncology

Malignant melanoma is still a serious medical problem. Relatively high mortality, a still-growing number of newly diagnosed cases, and insufficiently effective methods of therapy necessitate melanoma research. Tetracyclines are compounds with pleiotropic pharmacological properties. Previously published studies on melanotic melanoma...

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2021

  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: PBMCs
  • Assay: Cell Count & Viability Assay
  • Research area: Cell Biology

Measured variability of product within Cell and Gene Therapy (CGT) manufacturing arises from numerous sources across pre-analytical to post-analytical phases of testing. Operators are a function of the manufacturing process and are an important source of variability as a result...

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  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Mammalian Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Cell Biology

Previous studies revealed that direct contact with graphene oxide (GO) induced cytotoxic effects, but the importance of involvement of metabolic pathways, in particular lipid metabolism pathways, might be overlooked. In this study, human umbilical vein endothelial cells (HUVECs) were exposed...

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  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Mammalian Cells
  • Assay: Mitochondrial Potential Assay
  • Research area: Cell Biology

Oxidative stress has been implicated in the pathogenesis of Alzheimer’s disease (AD). Mitochondrial dysfunction is linked to oxidative stress and reactive oxygen species (ROS) in neurotoxicity during AD. Impaired mitochondrial metabolism has been associated with mitochondrial dysfunction in brain damage...

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2020

The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

  • Boisen IM, Rehfeld A, Mos I, et al. ,

  • The Journal of Clinical Endocrinology and Metabolism ,

  • 2020,

  • dgaa937

  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Sperm Cells
  • Assay: FlexiCyte™ Assay
  • Research area: Animal Reproduction

Context: The calcium-sensing receptor (CaSR) is essential to maintain a stable calcium concentration in serum. Spermatozoa are exposed to immense changes in concentrations of CaSR ligands such as calcium, magnesium, and spermine during epididymal maturation, in the ejaculate, and in...

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  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Yeast Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Brewing

Cellular senescence is defined by irreversible cell-cycle arrest and is an evolutionarily conserved hallmark of aging. In this study, we generate senescent microglial cells via exposure to the chemotherapy drug doxorubicin. Compared to control cells, doxorubicin-treated microglia exhibited an altered...

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Characterization of Human Mitochondrial PDSS and COQ Proteins and Their Roles in Maintaining Coenzyme Q 10 Levels and Each Other’s Stability

  • Hsiu-Chuan Yen , Wen-Yu Yeh , Szu-Hsien Lee , et al. ,

  • Biochim Biophysica Acta Bioenergetics ,

  • 2020,

  • 1861(7):148192

  • Instrument: NucleoCounter® NC-3000™
  • Cell Type: Mammalian Cells
  • Assay: Cell Count & Viability Assay
  • Research area: Cell Biology

Mutations of many PDSS and COQ genes are associated with primary coenzyme Q10 (CoQ10) deficiency, whereas mitochondrial DNA (mtDNA) mutations might cause secondary CoQ10 deficiency. Previously, we found that COQ5 and COQ9 proteins are present in different protein complexes in...

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