XcytoMatic® 40

High-throughput cell density analyzer

  • Fast processing time (~100 samples/hour)
  • Highest cell counting range yet: up to 100 million cells/ml
  • Consistent results across instruments, users and laboratories
  • Brightfield and fluorescent microscopy (trypan blue-free)
  • 21 CFR Part 11/GMP-ready software
When it comes to cell counting precision, we’re proud to be extreme. The XcytoMatic® 40 (XM40™) is a high-throughput cell density and viability analyzer that can run 24 samples in under 14 minutes. The variation between cell counts for these samples is under 3%. If scale-out and scale-up is a concern, you can trust each XM40™ instrument in your production to deliver the same quality results. The instrument-to-instrument variation for this model lies under 5%, supporting easy tech transfer.

We designed the XM40™ to support cGMP manufacturing of biologics, vaccines, and advanced therapies. How? By minimizing the required sample volume to just 50 µl, increasing the dynamic cell counting range to 100 million cells per milliliter, and allowing for 100 samples to be analyzed per hour.

New to this line of instruments, we added a brightfield channel—without trypan blue. Combined with fluorescence microscopy, the AI-powered XM-View™ software accurately tracks cellular debris buildup in your culture. It additionally measures cell diameter, providing added information about cell health.

This instrument reduces the use of consumables, with long-lasting rinsing and staining solutions—all handled automatically by the instrument. All you need to do is plug-and-play. Let the XM40™ take care of the rest.

Say goodbye to downtime and dilutions.

Say hello to the XM40™.

Application type(s) Cell count & viability analysis
Cell type(s) Mammalian cells, incl. cell lines and primary cells, whole blood samples, leukopaks, PBMCs, MSCs, T cells, yeast, insect cells, and aggregated cells
Software XM-View™
Consumable(s) XM Cell Stain 1, XM Rinse 1
Analysis volume 4.4 µl
Optimal range 5 x 104 – 1 x 108
Staining dye(s) Acridine orange (AO) and 4′,6-diamidino-2-phenylindole (DAPI)
Loading volume 50 μl
Excitation 2 LED light sources with peak wavelengths at 365 nm and 505 nm
Emission A single dual-band emission filter: 410 – 460 nm and 540 – 650 nm
Optics Lens with × 2.1 magnification, 2/3” CMOS camera
Data output Images, tables
Data export formats .cm, .csv, .pdf
Product Number
H: 430 mm x W: 440 mm x D: 524 mm
50 kg
Supply voltage
24 VDC (100-240 V ~ 50-60 Hz)

Sampling Devices, Reagents & Test Kits for the XcytoMatic® 40 Count 100 Samples/hour—Consistently.


Product type Product No. Product name
Software 950-0040 XM-View™
Reagents 910-0014 XM Cell Stain 1
  910-0017 XM Rinse 1
Accessories 929-0013 XM40 Carousel